This paper examines women's responsibility for social reproduction in South Africa. Drawing from a range of studies that analyze quantitative data, it considers how distinctive characteristics of South Africa's socio-economic landscape shape the nature of this responsibility. These characteristics include rates of paternal coresidence and marriage that are amongst the lowest in the world, unemployment and inequality rates that are amongst the highest, and continuing patterns of individual labor migration with race remaining a significant socio-economic stratifier. Given these features, women are not only most often the providers of caring labor in the household they are often also the financial providers. Women are responsible for social reproduction even when they are not wives or mothers, and this responsibility limits their access and returns to paid work. Gender asymmetries in who carries the economic costs of social reproduction are highlighted by evidence of both a motherhood earnings penalty and a male marital earnings premium in the South African labor market. In addition to economic measures, the paper reviews research on the noneconomic costs of social reproduction including life satisfaction and depression, and it highlights the importance of recognizing intersectionality in the well-being of women.