The global burden of non-communicable diseases (NCDs) is on the rise, and is expected to increase. The United Nations, through the 2030 Agenda for Sustainable Development Goals, acknowledged the public health importance of addressing NCDs, and set a goal to reduce premature mortality from NCDs by one-third by 2030. Key to achieving targets for prevention and control of NCDs is a holistic approach to understanding the underlying contextual causes. This thesis examines the role of inequality in socioeconomic status in the development of chronic diseases in South Africa, a highly unequal middle-income country battling
communicable diseases and maternal and child mortality. To achieve this, the study had three objectives: (1) To examine how exposure to negative household events and neighbourhood characteristics relates to systolic blood pressure in South Africa; (2) To determine socioeconomic factors that explain depressive symptoms in South Africa; and (3) To ascertain the influence of the COVID-19 pandemic on income-related inequality in depressive symptoms in South Africa