The interaction between family structure and household well-being has received considerable attention in research over the past decades. Very few studies, however, go beyond linking marital component of family structure with household income. This paper uses cross-sectional and panel analytic techniques with data from National Income Dynamic Survey (NIDS) to investigate the effects of family structure on household well-being. Findings from this study show that intact married and cohabiting households have significant positive relationship with household reported well-being, and subjective wellbeing, respectively. Furthermore, extended households, households headed by females and grandparents, have significant negative relationship with household income and consumption. Lastly, bigger household size has significant negative relationship with household reported well-being. Based on the findings, policy towards economic empowerment for poorer households, enhancing income generating, and livelihood projects are recommended.