Researches have been interrogating the influence of international migration on life satisfaction but ignoring the influence of internal migration on life satisfaction. This study therefore examined the influence of inter-provincial migration on life satisfaction in South Africa. Data for the study were from the fifth and latest wave of the National Income Dynamics Survey (NIDS) conducted in South Africa in 2017. Data were analyzed by descriptive statistics, Pearson Chi-square and ordinary least-square (OLS) regression. The results showed that the migrants (mean?=?5.73) had significantly (Chi?=?48.8; p?<?0.001) better life satisfaction than non-migrants (mean?=?5.54). In addition, there existed significant variations in the level of happiness (Chi?=?9.97; p?<?0.002), subjective income classification (Chi?=?16.8; p?<?0.001) and perceived physical health (Chi?=?8.65; p?<?0.002). Finally, the OLS coefficients showed that respondents with average and above average subjective income classification, respondents with good perceived physical health, respondents with happier happiness level, females, married respondents, non-Blacks, respondents earning higher than R5000, household with 7?+?persons and province of residence were associated with increased life satisfaction among migrants and non-migrants.