The South African Government declared October as Mental Health Awareness month. Recent studies in South Africa show that the risk of depression varies across socio-economic strata, with low-income individuals being more likely to have depressive symptoms than high-income individuals (Igboeli et al., 2021; Mungai and Bayat, 2019). In raising awareness about mental health and the socio-economic crisis in South Africa, this Map of the Month uses the GCRO Quality of Life (QoL) Survey dataset to analyse and map the spatial association between high risk of depression and socio-economic status in Gauteng. The mapping was done in geographic units known as mesozones and was based on two measures: the Patient Health Questionnaire-2 (PHQ-2) score, which is a screening tool for risk of depression, and a socio-economic status index.