Transport users make mode choices based on a variety of factors. These factors are economic or service driven, based on individual roles, habits, and interests, as well as age, life cycle stage, and gender. Analysis reflects different mobility patterns for males and females relating to care activities. Literature suggests that experiences of harassment have a significant effect on user choices. This study examines how South African data compares with international studies. Mode use and trip purposes, distances, and times differ depending on gender and are affected by the experience of harassment, which affects females more than males. Analyzing trip making in South Africa revealed that travel modes, distances, and times are not significantly different across gender. South African females make fewer trips than males, but significantly more care trips. Different modes of public transport score differently regarding potential experience of harassment, with trains performing the worst. The reason mode choice is not significantly different between females and males is assumed to be because of financial reasons. Investigating harassment perception in Cape Town reveals that females experience harassment more often and this influences their choices regarding care trips. These findings have significant implications for transport policy in South Africa and suggest that more nuanced policies are required.