The majority of seismic activity in South Africa is related to extensive mining operations, usually in close proximity to densely populated areas where a relatively weak seismic event could cause damage. Despite a significant decrease in mining operations in the Witwatersrand area, the number of seismic events appears to be increasing and is attributed to the acid mine drainage problem. The increased seismicity is raising concern amongst disaster management centres and in the insurance industry. A better understanding is required of the vulnerability and the size of the potential loss of people and infrastructure in densely populated Johannesburg and its surrounding areas. Results of a deterministic seismic risk, vulnerability, and loss assessment are presented by making use of a geographic information system (GIS). The results illustrate the benefits of using GIS and contribute to a better understanding of the risk, which can assist in improving disaster preparedness.