This study examined the influence of condom use on men’s sexual behaviour in the University of Ghana community. In all, 600 men were sampled for this study using stratified and simple random sampling techniques. The ages of respondents ranged from 17 to 74 years with a mean age of 24 years. The study found that while 80% men have ever used condom, a little over 50% of them used condom at their last sexual encounter. The study established that education and condom use is not related (p> 0.05).